How I treat thrombotic thrombocytopenic purpura and atypical haemolytic uraemic syndrome

Thrombotic thrombocytopenic purpura (TTP) and atypical haemolytic uraemic syndrome (aHUS) are acute, rare life-threatening thrombotic microangiopathies that require rapid diagnosis and treatment. They are defined by microangiopathic haemolytic anaemia and thrombocytopenia, with renal involvement primarily in aHUS and neurological and cardiological sequelae in TTP. Prompt treatment for most cases of both conditions is with plasma exchange initially and monoclonal therapy (rituximab in TTP and eculizumab in aHUS) as the mainstay of therapy. Here we discuss the diagnosis and therapy for both disorders

Lorentz Invariance Violation and the Observed Spectrum of Ultrahigh Energy Cosmic Rays

There has been much interest in possible violations of Lorentz invariance, particularly motivated by quantum gravity theories. It has been suggested that a small amount of Lorentz invariance violation (LIV) could turn off photomeson interactions of ultrahigh energy cosmic rays (UHECRs) with photons of the cosmic background radiation and thereby eliminate the resulting sharp steepening in the spectrum of the highest energy CRs predicted by Greisen Zatsepin and Kuzmin (GZK). Recent measurements of the UHECR spectrum reported by the HiRes and Auger collaborations, however, indicate the presence of the GZK effect. We present the results of a detailed calculation of the modification of the UHECR spectrum caused by LIV using the formalism of Coleman and Glashow. We then compare these results with the experimental UHECR data from Auger and HiRes. Based on these data, we find a best fit amount of LIV of $4.5^{+1.5}_{-4.5} \times 10^{-23}$,consistent with an upper limit of $6 \times 10^{-23}$. This possible amount of LIV can lead to a recovery of the cosmic ray spectrum at higher energies than presently observed. Such an LIV recovery effect can be tested observationally using future detectors.Comment: corrected proof version to be published in Astroparticle Physic

Is the Universe More Transparent to Gamma Rays Than Previously Thought?

The MAGIC collaboration has recently reported the detection of the strong gamma-ray blazar 3C279 during a 1-2 day flare. They have used their spectral observations to draw conclusions regarding upper limits on the opacity of the Universe to high energy gamma-rays and, by implication, upper limits on the extragalactic mid-infrared background radiation. In this paper we examine the effect of gamma-ray absorption by the extragalactic infrared radiation on intrinsic spectra for this blazar and compare our results with the observational data on 3C279. We find agreement with our previous results, contrary to the recent assertion of the MAGIC group that the Universe is more transparent to \gray s than our calculations indicate. Our analysis indicates that in the energy range between ~80 and ~500 GeV, 3C279 has a best-fit intrinsic spectrum with a spectral index ~1.78 using our fast evolution model and ~2.19 using our baseline model. However, we also find that spectral indices in the range of 0.0 to 3.0 are almost as equally acceptable as the best fit spectral indices. Assuming the same intrinsic spectral index for this flare as for the 1991 flare from 3C279 observed by EGRET, viz., 2.02, which lies between our best fit indices, we estimate that the MAGIC flare was ~3 times brighter than the EGRET flare observed 15 years earlier.Comment: version accepted for publication in ApJ Letter

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Corrected Table for the Parametric Coefficients for the Optical Depth of the Universe to Gamma-rays at Various Redshifts

Table 1 in our paper, ApJ 648, 774 (2006) entitled "Intergalactic Photon Spectra from the Far IR to the UV Lyman Limit for 0 < z < 6 and the Optical Depth of the Universe to High Energy Gamma-Rays" had erroneous numbers for the coefficients fitting the parametric form for the optical depth of the universe to gamma-rays. The correct values for these parameters as described in the original text are given here in a corrected table for various redshifts for the baseline model (upper row) and fast evolution (lower row) for each individual redshift. The parametric approximation is good for optical depths between 0.01 and 100 and for gamma-ray energies up to ~2 TeV for all redshifts but also for energies up to ~10 TeV for redshifts less than 1.Comment: Table 1 corrected and new gamma-ray energy range of validity give

A dynamic scheme for generating number squeezing in Bose-Einstein condensates through nonlinear interactions

We develop a scheme to generate number squeezing in a Bose-Einstein condensate by utilizing interference between two hyperfine levels and nonlinear atomic interactions. We describe the scheme using a multimode quantum field model and find agreement with a simple analytic model in certain regimes. We demonstrate that the scheme gives strong squeezing for realistic choices of parameters and atomic species. The number squeezing can result in noise well below the quantum limit, even if the initial noise on the system is classical and much greater than that of a poisson distribution.Comment: 4 pages, 3 figure

Intergalactic Photon Spectra from the Far IR to the UV Lyman Limit for 0<z<60 < z < 6 and the Optical Depth of the Universe to High Energy Gamma-Rays

We calculate the intergalactic photon density as a function of both energy and redshift for 0 < z < 6 for photon energies from .003 eV to the Lyman limit cutoff at 13.6 eV in a Lambda-CDM universe with $\Omega_{\Lambda} = 0.7$ and $\Omega_{m} = 0.3$. Our galaxy evolution model gives results which are consistent with Spitzer deep number counts and the spectral energy distribution of the extragalactic background radiation. We use our photon density results to extend previous work on the absorption of high energy gamma-rays in intergalactic space owing to interactions with low energy photons and the 2.7 K cosmic background radiation. We calculate the optical depth of the universe, tau, for gamma-rays having energies from 4 GeV to 100 TeV emitted by sources at redshifts from ~0 to 5. We also give an analytic fit with numerical coefficients for approximating $\tau(E_{\gamma}, z)$. As an example of the application of our results, we calculate the absorbed spectrum of the blazar PKS 2155-304 at z = 0.117 and compare it with the spectrum observed by the H.E.S.S. air Cherenkov gamma-ray telescope array.Comment: final version to be published in Ap

A Determination of the Intergalactic Redshift Dependent UV-Optical-NIR Photon Density Using Deep Galaxy Survey Data and the Gamma-ray Opacity of the Universe

We calculate the intensity and photon spectrum of the intergalactic background light (IBL) as a function of redshift using an approach based on observational data obtained in many different wavelength bands from local to deep galaxy surveys. This allows us to obtain an empirical determination of the IBL and to quantify its observationally based uncertainties. Using our results on the IBL, we then place 68% confidence upper and lower limits on the opacity of the universe to gamma-rays, free of the theoretical assumptions that were needed for past calculations. We compare our results with measurements of the extragalactic background light and upper limits obtained from observations made by the Fermi Gamma-ray Space Telescope.Comment: 32 pages, 6 figures, Accepted for publication in the Astrophysical Journa